Review article: tegaserod -- the global experience.
نویسنده
چکیده
Studies from the Western hemisphere have established the efficacy and safety of tegaserod in women with irritable bowel syndrome and constipation. This review summarizes the results of recent studies from around the world that confirm the efficacy and safety of tegaserod, and expand our understanding of the role of this drug in the treatment of patients with irritable bowel syndrome.
منابع مشابه
Safety and efficacy of tegaserod therapy in patients with irritable bowel syndrome or chronic constipation.
BACKGROUND Tegaserod, a 5-HT4 agonist, is effective for treating irritable bowel syndrome and chronic constipation. However, sales of this drug were recently suspended due to concerns about a higher rate of cardiovascular events in patients receiving tegaserod over placebo in clinical trials. Our aim was to review patients in our practice prescribed tegaserod to determine if any of them had suf...
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The aim of this article is to review the pathophysiology and clinical role of serotonin receptor modulators used in the treatment of irritable bowel syndrome. Serotonin is an important monoamine neurotransmitter that plays a key role in the initiation of peristaltic and secretory refl exes, and in modulation of visceral sensations. Several serotonin receptor subtypes have been characterized, of...
متن کاملReview: tegaserod prompts global relief of symptoms in irritable bowel syndrome.
M e t h o d s Data sources: MEDLINE (1966 to 2002), EMBASE/Excerpta Medica (1980 to 2002), Science Citation Index, the Cochrane Central Register of Controlled Trials, the Cochrane Inflammatory Bowel Disease Review Group Specialized Trials register, databases of ongoing trials, the U.S. Food and Drug Administration, and lists of conference abstracts. Bibliographies of relevant articles were scru...
متن کاملSafety and Tolerability of Tegaserod for Irritable Bowel Syndrome
INTRODUCTION Tegaserod maleate (ZelnormTM, Novartis) is a unique pharmacological agent for the treatment of patients with irritable bowel syndrome (IBS) with constipation (IBS-C). Unlike traditional IBS therapies, which target only single IBS symptoms, tegaserod has provided global relief of the multiple symptoms of IBS, including abdominal pain and discomfort, bloating, and constipation.1–4 It...
متن کاملTegaserod for the treatment of irritable bowel syndrome and chronic constipation.
BACKGROUND IBS is a complex disorder that encompasses a wide profile of symptoms. The symptoms of chronic constipation frequently resemble those of constipation-predominant IBS. Current drug treatments for irritable bowel syndrome (IBS) are of limited value. Many target specific symptoms only. Tegaserod, a 5HT(4) partial agonist, represents a novel mechanism of action in the treatment of IBS an...
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ورودعنوان ژورنال:
- Alimentary pharmacology & therapeutics
دوره 20 Suppl 7 شماره
صفحات -
تاریخ انتشار 2004